ISRM-17 is manually operated microtome, used to produce thin section of specimens of different hardness in both routine and research applications in Laboratory, pathology and Histopathology,biology, medicine and institutes. The instrument ensures lifelong smooth operations. Individual components are fabricated and assembled from selected material using assembled from selected material using latest technology. Ball and flange object clamp provides flexible orientation of object piece. Latest cam system eliminates the conventional cord system for feeding, resulting in better section cutting and improved efficiency of the machine.